At Wellness First Psychiatric Associates, we provide generic ketamine therapy in combination with psychotherapy to help patients safely explore, reframe, and resolve deeply rooted emotional distress. Our Durham clinic integrates cutting-edge neuroscience with thoughtful therapeutic care to support healing from depression, trauma, PTSD, and anxiety.

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We believe that ketamine is most effective when used as a bridge — a catalyst that opens new psychological space — rather than as a stand-alone solution. Our approach reflects the guiding philosophy of Wellness First: healing occurs through understanding, integration, and genuine human connection.

🌿 Why Ketamine?

Ketamine is a long-established medication originally developed as an anesthetic and used for decades in medicine. In recent years, researchers have discovered that it can provide rapid relief of depression and suicidal thinking, even in individuals who have not responded to standard treatments.

Unlike Spravato (the branded nasal formulation), generic ketamine allows for more flexibility in clinical use and can be tailored to each patient’s needs. It has shown promise not only for treatment-resistant depression but also for PTSD, anxiety, and substance-related disorders.

Scientific studies continue to expand our understanding of how ketamine acts on the brain — enhancing neural plasticity and allowing new patterns of thought and emotion to emerge. When integrated with therapy, these effects can help patients approach painful memories with new perspective and resilience.

🧩 Ketamine and Psychotherapy: A Combined Approach

Research led by Dr. John Krystal and others at Yale has highlighted how ketamine creates a “window of neuroplasticity” — a period in which old patterns and traumatic memories can be safely revisited and reframed.

At Wellness First, we build upon this work through a two-step process:

1. The Ketamine Session – conducted in a calm, supportive environment under professional supervision. Patients are guided to remain open to their internal experience rather than resist it.

2. The Integration Session – scheduled within 48 hours, when the brain’s capacity for change remains heightened. During this session, the therapist helps validate and reinforce the insights gained, consolidating the experience into lasting psychological growth.

This combined approach allows patients to translate the biological effects of ketamine into meaningful therapeutic change — strengthening insight, hope, and emotional flexibility.

💬 What to Expect from Treatment

• Comprehensive assessment: Each patient receives a thorough psychiatric and medical evaluation to ensure safety and suitability.

• Individualized plan: Treatment frequency and dosage are tailored to each person’s needs and goals.

• Therapeutic support: Sessions are conducted in collaboration with your therapist or one of our in-house clinicians.

• Integration: A follow-up therapy visit helps process insights and prevent relapse.

• Ongoing care: Many patients continue psychotherapy or other treatments alongside ketamine to maintain long-term stability.

🌈 Is Ketamine Right for You?

Ketamine therapy may be an option if traditional antidepressants or psychotherapy have provided only partial relief. It can be particularly helpful for individuals living with:

• Major depressive disorder

• PTSD and trauma-related conditions

• Anxiety or obsessive thoughts

• Emotional numbing or loss of connection

Because ketamine is not appropriate for everyone, our clinicians review each case carefully and provide clear guidance about the potential benefits and limitations of treatment. Safety, informed consent, and integration are central to our approach.

📍 Our Philosophy

Our team believes that the mind has a natural drive toward healing. Ketamine can help reawaken that capacity when guided by a compassionate therapeutic relationship. At Wellness First Psychiatric Associates, we combine biological insight with psychological understanding to help patients find renewed balance, purpose, and connection to life.

📞 Learn More

To learn more about Ketamine-Assisted Psychotherapy in Durham, NC, or to schedule an initial consultation, please contact our office or visit the Forms page to review our informed consent for generic ketamine therapy.